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TISSUE LIPID PROFILE OF
RATS ADMINISTERED AQUEOUS EXTRACT OF HIBISCUS ROSA-SINENSIS.
LINN.
Kate E. Imafidon
Biochemistry Department, Faculty of life Sciences, University of Benin, Benin
City, Edo state, Nigeria
ABSTRACT
The effect of orally administered aqueous extract of the leaves of Hibiscus rosa-sinensis on tissue lipid profile of albino rats has been determined. Consequently 20 albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 4 weeks, during which they were subjected to different dosages of the aqueous extract. Group I (control) received an equivalent volume of water, group II, 200mg/Kg body weight of extract, group III, 500mg/Kg body weight, while group IV, 700mg/Kg body weight of crude extract. Results showed a dose dependent increase in liver triacylglycerol, total cholesterol and LDL cholesterol concentrations of rats and a decrease in heart triacylglycerol, total cholesterol and LDL cholesterol concentrations compared with control. Kidney lipid profile of the rats was unaffected. This result suggests a dose dependent alterations in liver metabolism.
