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  Contents of Volume 7, No.2 2011 | Download PDF file for Prin

 

THE EFFECT OF CEDRUS DEODARA ROOT OIL ON THE HISTOPATHOLOGY OF RAT STOMACH

Ijaz Hussain Zaidi*, Syed Naeemul Hasan Naqvi, Qamar Aziz, R.M. Tariq, Aneela Qureshi, Mazhar Hussain Hijazi, Muhammed Ahmed Azmi, Shabih Zehra and Rehana Parveen
Department of Casualty, P.N.S Shifa Hospital, DHA, Phase 2, Karachi
Department of Pharmacology, Anatomy & Physiology, Baqai Medical University, Toll Plaza, Gadap Town, Karachi
Departments of Physiology, Pathology & Radiology, Al-Tibri Medical College, Old Thana Gadap, Malir Town, Karachi
MAH Qadri Biological Research Centre, University of Karachi
ABSTRACT
The aim of this study was to observe the anti-ulcer effects of Cedrus deodara root oil on the rat’s stomach and compare it with standard anti-ulcer drugs, femotidine and protonix. The study was conducted on 50 albino Wistar rats in three different doses i.e. 30, 40, and 50 mg/kg. The animals were divided into five groups, each group comprised of 10 rats (5 male and 5 female). The oil was extracted from the plant root by dry destructive distillation method and the dose was calculated by dissolving 1.25 gms of Cedrus deodara in 25ml of 10% ethanol. The drugs were administered to the treated animals orally through feeding tube for two weeks. Animals received the dose of 50 mg cedar oil only, showed the healing effects on the mucosal epithelium of stomach, decreased inflammatory cells and granulation tissues on the submucosal layer upon histopathological examination. Therefore it may be concluded that Cedrus deodara root oil has anti-ulcerative effects and may be used in the management of gastrointestinal disorders particularly in peptic ulcer.
Keywords: Histopathology, Cedrus deodara root oil, Stomach, Anti-ulcer drugs, Albino rats.