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STUDIES OF KETOPROFEN TOXICITY IN AVIAN SPECIES

Asif Farooq Awan, Taha Nazir*, Muhammad Ashraf, Owais Umer and Habib Ur Rehman
Services Hospital, Ministry of Health, Government of the Punjab, Jail Road, Lahore, Pakistan
School of Pharmacy, The University of Lahore, Islamabad Campus, 24 Jinnah Avenue, Blue Area, Islamabad, Pakistan
Faculty of Bio-Sciences, University of Veterinary & Animal Sciences, Lahore, Pakistan
ABSTRACT
Certain environmental factors are very important to stabilize the wild life; avian diseases, vulture crises and ecological annoyance. This should be fixed scientifically to minimize the health hazards. Thus; we have aimed this project to evaluate effects of toxic dosage levels of Ketoprofen in broiler chickens. Two hundred and twenty five (225) healthy broiler chickens were reared upto 28 days and divided into five groups 25 birds in each group. On day 29th four groups were medicated twice a day at dose rate of 50 mg/kg body weight respectively intra-muscularly for four days. Feed and water were provided ad libitum. A physical examination, toxicity and mortality rate were recorded daily. Blood samples was drawn to determination the serum values of Aspartate Transaminase (AST), Alanine Transaminase (ALT), Uric Acid, Alkaline phosphatase (ALP), and Creatinine. Postmortem performed on day 41 after all samples taken. In second experiment other 100 birds were divided into five groups comprising of 20 birds in each group. One of the groups was injected I/M Ketoprofen 5mg/kg twice a day. Postmortem performed after medication on 5th day. Based on the necropsy findings and biochemical analysis it was found that Ketoprofen was not safe drug in the avian species. Keeping in view the environmental problem (vultures crises) it is recommended that Ketoprofen which has good pharmacological effects in human medicine should be avoided in veterinary practice.
Keywords: Ketoprofen toxicity, Broiler birds, LFT’s